Statin Selection or Substitution. … Drug Comparisons Statins (HMG-CoA Reductase Inhibitors) ' -- ' Signifies that equivalent tablet size is not available (comparable dose is either too high or too low) Drug Comparisons - Home … The following are guideline recommendations for statin treatment: Patients ages 20-75 years and LDL-C ≥190 mg/dl, use high-intensity statin without risk assessment. intensity statin if: LDL > 160 mg/dl, family history, hs CRP > 2, CAC>300 or 75%, ABI < .9, or high lifetime risk. Manufacturer: Merck Pros: potent at raising HDL cholesterol. T2DM and age 40-75 years, use moderate-intensity statin and risk estimate to consider high-intensity statins. FIGURE. However, expert recommendations lean toward a moderate-intensity or high-intensity statin. It was the statin used in the 20,000-patient Heart Protection Study, showing a reduced risk of heart attack at all LDL cholesterol … Clinical atherosclerotic cardiovascular disease LDL-C ≥ 190 mg/dl Type 1 or 2 Diabetes age 40-75 Age 40-75 Estimated 10 yr atherosclerotic CVD risk > 7.5% High-Intensity Statin … Some are more potent than others. Simplified flow chart of major considerations for statin selection or substitution. Statin Treatment Recommendations. There are several different types of statins. Statins 101.

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