Payton was the all-time leading rusher in the history of the National Football League. Walter's cause of death was primary sclerosing cholangitis. In April of that year, Payton made a final public appearanc… It was well known that he had a progressive liver disease called primary sclerosing cholangitis . However, the cause of Mr. Payton's death was bile duct cancer , said Dr. Greg Gores, his physician at … Walter passed away on November 1, 1999 at the age of 45 in South Barrington, Illinois, USA. An excerpt of "Sweetness: The Enigmatic Life of Walter Payton," by Jeff Pearlman, will appear in the Oct. 3 issue of Sports Illustrated, and describes the … He spent his final months as an advocate for organ transplants, appearing in many commercials to encourage others to donate organs, although by the time his first appeal was recorded, his illness was already too far advanced for transplantation to have been a viable option. In February 1999, Payton announced that he had a rare liver disease known as primary sclerosing cholangitis, which may have led to his cholangiocarcinoma (bile duct cancer). Walter Payton Death.

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